The ex-Ghana captain is reported to have agreed a two-year deal on Tuesday after meeting the Executive Committee.
Appiah was appointed the substantive coach of the Black Stars after four years as an assistant coach.
His first assignment will be against the Crocodiles of Lesotho on June 3 at home in a 2014 World Cup qualifier.
”The first target is to qualify us to the World Cup and also qualify us to the Nations Cup, Nyantakyi said.
”At he World Cup we said our target is to reach the semi-final; Nations Cup our target is to win.
“We reckon that a lot of things go into performance so we are not going to judge only on the basis of achieving or not achieving the target but the overall performance.”
Appiah is yet to name his assistant coach ahead of his unveiling next Tuesday.
Source: MTNFootball Ghana